ISMBE 2020

The Impact Kinetic Force in the Acute Aortic Dissections and Ruptures is ONE, in Three Different Appearance Forms

author.DisplayName 1 author.DisplayName 2 author.DisplayName 4 author.DisplayName 3 author.DisplayName 1 author.DisplayName 1
1Royal Brompton and Harefield Hospitals NHS Foundation Trust, UK
2Cleveland Clinic Foundation, Abu Dhabi, United Arab Emirates
3Klinikum Hirsladen Zürich, Switzerland
4The London Bioscience and Innovation Centre, UK

Objective: Acute aorrtic dissection (AAD) is life threatening disease with very high early mortality and morbidity rate in humans.

Methods: Our results based on our investigations, which shows that the main factor initiating AAD is a direct development from a high energy kinetic force factor, genetated from interaction of pathological blood flow turbulences. Aortic wall hematom (AWH) is one form of the AAD and it is the silent but high risk variantion of AAD, without entry or re-entry on the aortic wall, which occasinally observed as a frequent side effect at kidney stone high energy shock wave litotripsy either. This demostrates the point that the impact force at AAD is also a high energy shock wave /high energy resonance/ which ruptures the cappilaries inside the aortic wall and not the relative law energy scale and continuous wall and shear forces.results: These phenomenon descibed above is a blood mass -- kinetic energy interaction having a relative negative vector. It rise in, elevates the vessel wall in the other two AAD-s, either only the intima or the media or the entire aortic wall as well. The above pathophysiology might derive from the fact that the healthy wall of the mammalian vascular system has a "Given Nature" ability to tolerate extrem high blood pressure (10x the normal) from inside out only, as multiply G-forces as the space or military pilots, Valsalva Manoeuver at professional weightlifters, but can not tolerate high scale force in the opposite vector direction.

Conclusion: A simplified mathemathical formula : kinetic force vector from blood vortex collisions devided by the actuell aortic wall resistance allow us the correct prognosis for only a localised intima injury only or for a complete maybe lethal acute aortic wall dissection.









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