Predicive Factors of Early Recurrence after Curative Surgery in Stage 1 and 2 Pulmonary Adenocarcinoma

Back ground

Although surgery is the most effective treatment of early stage non-small cell lung cancer, postoperative recurrence has been occurred occasionally. The purpose of this study is to find the predictive factors for early recurrence after curative surgery in stage I and II pulmonary adenocarcinoma.

Methods

Between 2011 and 2013, 279 patients underwent curative surgery for stage I or II pulmonary adenocarcinoma. Early recurrence was defined as recurrence within 2 years after surgery. Recurrence-free survival and clinicopathological factors associated with recurrence were analysed using the Kaplan-Meier method and Cox propotional hazards model.

Results

Of the 279 patients, 30 patients experienced early recurrence. Locoregional recurrence was 19 cases and distant recurrence was 11 cases. Mean follow up duration was 760.9days. 3-years recurrence free survival was 88.4% in stage I and 64.0% in stage II. Multivariate analyses showed that micropapillary component(>5% of tumor) was significantly associated with early recurrence (p=0.043, HR 3.110), especially locoregional recurrence(p=0.006, HR 7.406).

Conclusion

Micropapillary component had a significant effect on early recurrence especially locoregional recurrence after curative surgery for pulmonary adenocarcinoma.