Microwave ablation (MWA) is a minimally invasive therapy to treat malignant tumors. This research studies the effect of frequency on the efficiency of MWA of liver cancer. Frequency band of 1-12 GHz is considered. The combined EM and bio-heat simulations indicate that at higher frequencies the ablated area is comparable in size to that obtained at lower frequencies, but it is more spherical and no sleeve is required to choke RF currents that heat healthy tissues along the applicator coax.