Does Permanent Cardiac Stimulation Through B – Natriuretic Peptide Secretion Influence the Basic Parameters of Renal Function?

Background: Aberrant waveform during artificial pacing increases secretion of natriuretic peptides, mainly B-type natriuretic peptide (BNP).

Aim: To investigate whether renal function is modified through increased BNP secretion during artificial pacing.

Material and Methods: A total of 117 patients with pacemaker implanted were included (pacing mode: AAI/R – 21, DDD/R – 59, VVI/R – 37) and 48 healthy volunteers served as controls. Serum BNP, creatinine and urea levels were measured prior to, three and six months after pacemaker implantation.

Results: Three and six months after implantation BNP level significantly increased in DDDR group, urea level increased in AAIR group whereas creatinine level increased in DDDR and VVIR group.

Conclusions: In patients after pacemaker implantation BNP level increases in DDDR pacing mode group whereas in other modes it remains stable. Pacemaker implantation leads to changes in renal function. B-type natriuretic peptide level may serve as a useful parameter for renal and cardiac function assessment after pacemaker implantation.