FXYD5 is a Cancer Associated Protein that May Promote Tumorgenicity by Stimulating Secretion of the Chemokine CCL2 (MCP-1)

FXYD5 (dysadherin or RIC) interacts with Na⁺/K⁺ ATPase and alters its kinetics by increasing V_max. It also is a cancer associated protein whose expression inhibits E-Cadherin and promotes metastasis. The abundance of FXYD5 correlates to progression of malignancies and survival. Silencing FXYD5 decreases cell motility, while overexpression stimulates it. FXYD5 is also associated with cytoskeletal organization, cell shape, and impairment of tight and adherence junctions.

The chemokine CCL2 (MCP-1) participates in monocyte recruitment during infection. Many tumors secrete CCL2 which attracts macrophages that promote tumor growth, angiogenesis, and metastasis. This study shows that FXYD5 expression strongly increases CCL2 secretion.