NOVEL MULTI-FUNCTIONAL DRUGS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS – ANTIOXIDANT EFFECTS

Oxidation of proteins, lipids and DNA by reactive oxygen species (ROS) plays an important role in the aetiology of Alzheimer and Parkinson’s diseases, ischemic stroke and a variety of inflammatory diseases. Previously, we reported that indoline derivatives substituted with propionate ester or propylamino groups at position 3, protected cells from cytotoxicity induced by ROS.

The current study describes the synthesis and biological evaluation of novel indolines in which the side chains were: CH₂CH₂COOMe, CH₂CH₂CH₂NH₂, CH₂CH₂CH₂NH-i-Pr or CH₂CH₂CH₂OH, attached to the N, position 1, in the indoline ring.