Rational design of multi-component systems in the form of co-crystals can lead to the development of new materials with desired properties and functions.1 Co-crystals are crystalline solids composed of two or more molecular components that interact with each other through non-covalent forces.2 Among the various non-covalent interactions, such as van der Waals, π-π interactions, and hydrogen bonding, halogen bonding (XB) is particularly interesting due to its directionality, bond strength, and structure directing capabilities.3 In this work, a tetrahedral pyridine-based ligand was used as the XB acceptor and various fluoroiodides were used as XB donors. Slow evaporation from solutions of XB donor and acceptor constituents resulted in formation of halogen-bond 3D networks spanned with continuous channels of 300 Å3 - 800 Å3 per unit cell. Minor differences in the structure of the components directed the organization of 3D networks that were obtained under identical conditions. The XB networks were characterized by single-crystal X-ray diffraction.