RECENT ADVANCES IN AUTOMATED OLIGOSACCHARIDE AND GLYCOPEPTIDE SYNTHESIS

The automated solid-phase synthesis of oligopeptides and oligonucleotides had an immense impact on biochemical research and has fulfilled the growing demand of the scientific community to study short biopolymers and their biological, biophysical and mechanical characteristics.

There is a major interest in developing robust methods for the synthesis of glycopeptides and oligosaccharides as their chemical synthesis requires compatible solutions for challenges associate with glycan assembly. The quest for solid phase strategy suitable for oligosaccharide and glycopeptide synthesis is still in the critical and stimulating stage of continuous development.

Automated solid-phase oligosaccharide synthesis has been developed to provide ready to use complex carbohydrates to the research community. Many important chemical and technological milestones have been achieved in the process of creating a reliable automated oligosaccharide synthesis system.

The developments in the automated solid-phase synthesis of oligosaccharides emphasize the contribution of adjacent fields such as NMR and flow chemistry to carbohydrate synthesis.

This study demonstrates that the new generation of oligosaccharide synthesizers overcome many technical and chemical hurdles and simplifies the synthesis of ready to conjugate oligosaccharides and glycopeptides.