Characteristics and Outcomes of Diabetic Patients with an Implantable Cardioverter Defibrillator in a Real World Setting: Results From the Israeli ICD Registry

Aims: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the risk of appropriate and inappropriate ICD therapy in patients with or without DM.

Methods and Results: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing [ATP] and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry. We also compared the risks of inappropriate ICD therapy, and death or cardiac hospitalization between diabetic and non-diabetic patients. Diabetic patients were older, were more likely to have ischemic cardiomyopathy, lower ejection fraction, atrial fibrillation, and other co-morbidities. The 3-year cumulative incidence of appropriate ICD therapy was similar in the DM and non-DM groups (Figure). Multivariate analysis showed that DM did not affect the risk of appropriate ICD therapy (HR = 1.07, 95% CI 0.78-1.47, p=0.694) or inappropriate therapy (HR=0.72, 95% CI 0.42-1.23, p=0.232). However, DM was associated with a 31% increased risk for death or cardiac hospitalization (p= 0.005). Results were similar in subgroup analyses including ICD and CRT-D recipients, primary or secondary prevention indication for an ICD.

Conclusions: Despite a significant excess of cardiac hospitalizations and mortality in the diabetic population, there was no difference in the rate of ICD treatments, suggesting that the outcome difference is non-arrhythmic.