Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) does not Improve Miscarriage Rate for Patients with Recurrent Implantation Failure and/or Male Factor Infertility

A new approach of Assisted Reproductive Technology (ART) involving real-time and high- magnification technique of spermatozoa together with a micromanipulation system called IMSI has taken place over a decade to improve the efficiency of the conventional Intracytoplasmic sperm injection (ICSI).

The intracytoplasmic morphologically selected sperm injection (IMSI) is based on motile sperm organellar morphology examination (MSOME) which involves the use of differential interference contrast microscopy at high magnification (at least x6300). This real-time system enables the selection of the best available motile spermatozoa before oocyte injection but requires more human time to perform it in comparison to the conventional ICSI procedure.

Several randomized control trials and other comparative studies have reported better clinical outcomes such as clinical pregnancy, miscarriage and live birth rates, in couples with previous recurrent implantation failure (RIF) and/or male factor infertility (MF) undergoing IMSI versus ICSI.

The aim of the present study is to confirm improved clinical outcomes in light of what has been published.

Our current study show that interestingly the miscarriage rate is higher in the IMSI group compared to the ICSI group which has not strengthened previous conclusions regarding less miscarriage rate after performing IMSI.