Application of Thrombelastography to Monitor The Change of Coagulation Function in Patients of Recurrent Spontaneous Abortion with Different Times Miscarriages Before and After Pregnancy

Background: The occurrence of recurrent spontaneous abortion(RSA) is associated with maternal prothrombotic state, which means that patients with RSA have more serious hypercoagulable state than other healthy women in childbearing years. Therefore, people with RSA are at increased risk of coagulation dysfunction. The thrombelastography (TEG) can measure whole blood clotting to reflect the blood coagulation function . We want to know whether there are differences in coagulation function among patients with different number of miscarriages before and after pregnancy according to TEG ,so that we can make more detailed plan to guide anticoagulant therapy of different times abortions. Objective: To explore the change of the TEG in patients with RSA in different number of miscarriages.

Methods: Selected 126 cases of patients with RSA as the research objectS, in which there are 101 cases of pregnant patients and 25 of non-pregnant patients to compare TEG changes between two groups of patients.Selected 101 with RSA as the research object, in which there are 52 cases of patients with two times miscarriages , 27 cases with three times miscarriages and 22 cases with greater than or equal to four times miscarriages to compare TEG changes between three groups of patients. Result: (1)MA values of patients with greater than or equal to four times miscarriages, which were significantly increased than patients with two or three times miscarriages.; (2)Angle values of pregnant patients were（66.39±5.175）°,which were significantly increased than non-pregnant patients（64.16±4.967）°（P＜0.05).

Conclusion: Coagulation function of RSA patients is associated with pregnancy and abortion times . Increased abortion times and pregnancy state of RSA patients show more obvious hypercoagulable state.TEG can found changes of the blood coagulation function early and sensitively,which may provide better guidance for
anticoagulant managements.