Markers of inflammation in patients with myocardial infarction with various psychological status

The aim of this research is to investigate the markers of inflammation in patients with postinfarction cardiosclerosis with various psychological status.

Methods

The study involved 318 patients with post-infarction cardiosclerosis aged 60.0 (53.0-67.0) years. Depending on the outcome in these patients during the first year after myocardial infarction (MI), the following groups were formed: a group with myocardial reinfarction (n = 56), a group of patients who died due to cardiovascular causes (n = 21) and a group without reinfarction (n = 241).

Results

Patients with poor outcome were characterized by higher rates of depressive disorders, reactive and personal anxiety, a large proportion of people with type D personality, lower rates of health-related quality of life. Patients with poor outcome during the first year after myocardial infarction (myocardial reinfarction or death) had higher average values of pro-inflammatory cytokines, and high-sensitivity C-reactive protein (HsCRP – 4.7(3.7-5.8) mg/l and 4.3 (4.1-5.6) mg/l against 1.85 (1.4-2.9) mg/l (p<0.001; p<0.001), TNF-α - 9,5 (4.3-16.1) pg/ml and 11.7 (8.9-19.0) pg/ml against 3.3 (2.8-9.5) pg/ml (p<0.01; p<0.001), IL-1β – 3,4 (2.3-4.7) pg/ml and 1.55 (1.3-2.9) pg/ml against 1.2 (1.0-1.3) pg/ml (p<0.001; p <0.001), IL-6 - 8.85 (5.6-12.3) pg/ml and 11.45 (7.5-15.2) pg/ml against 4.5 (2.7-6.7) pg/ml (p<0.001; p<0.001).