Association between Trombophilia and Prothrombotic Gene Polymorphisms and Risk of Reproductive Losses in Women - WCRPL2017 – 2nd World Congress on Recurrent Pregnancy Loss, 19-22, January 2017, Cannes, France

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¹laboratory of immunohematology, Kirov Research Institute of Hematology and Blood Transfusion, Russia
²research-clinical department, Kirov Research Institute of Hematology and Blood Transfusion, Russia
³doctor of the first hematology department, Kirov Research Institute of Hematology and Blood Transfusion, Russia
⁵director, Kirov Research Institute of Hematology and Blood Transfusion, Russia

Background: Reproductive failure is one of the leading in modern obstetrics and gynecology, as well as in the social policy of any state. Causes of fertility disorders is very diverse, but a special place among them is thrombophilia, as hereditary and acquired. Given the nature of the physiological adaptation of the haemostatic system to pregnancy, the vast majority of genetic thrombophilia is clinically manifested during the gestational process, both in the form of thrombosis, as well as in the form of common obstetric complications.Objective. To rate of the distribution of thrombophilia andprothrombotic gene polymorphisms (F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1) in women with reproductive losses and without fertility dysfunction.

Methods: The study was performed by polymerase chain reaction. For statistical processing of data was used criterion χ2.

The distribution of thrombophilia and prothrombotic gene polymorphisms in 629 women were analyzed:

group 1 - 105 women with primary infertility;
group 2 - 163 with delivery at term and reproductive loss in anamnesis;
group 3 – 70 with difficult labor (castling birth, severe preeclampsia, placental abruption);
group 4 – 93 with 2 recurrent pregnancy loss;
group 5 – 84 with 3 or more missed abortions.
Control group - 114 women without obstetric complications, with two or more than term labor.

Results. The frequency of occurrence of thrombophilia and prothrombotic gene polymorphisms are presented in the table.

Thrombophilia and prothrombotic gene polymorphisms in women with various obstetric history

The data of our study showed that the heterozygous form of the gene ITGВ3 met more often in women with primary infertility and difficult labor than women from the control group (p<0.05). Differences in the distribution of other thrombophilia and prothrombotic gene polymorphisms were not detected (p>0.05).

Conclusions: In this study, the influence of the ITGB3 genotype T/C at the non-coming of pregnancy and complications in childbirth. Differences in the distribution of other thrombophilia and prothrombotic gene polymorphisms in women with complicated obstetric history as compared to the control group not found (p> 0.05).