THE USE OF ULTRAVIOLET BLOOD MODIFICATION IN COMPLEX TREATMENT OF PATIENTS WITH ACUTE CORONARY SYNDROME WITHOUT ST-SEGMENT ELEVATION

The aim of the study was to investigate the effectiveness of including ultraviolet blood

modification into complex therapy of patients with ACS.

Patients and methods

45 patients with ACS without ST-segment elevation were examined in the course of

complex therapy including 30 patients with UVBM and 15 patients of the control group

who received conventional medical therapy. Ultraviolet irradiation of blood was carried

out with the use of a special device for ultraviolet irradiation. The blood from

the cubital vein was exposed to ultraviolet for 20 minutes and then returned to the patient.

This procedure was performed daily for 5 days.

Results

UVBM increased partial thromboplastin time from 29,9±1,5 sec. to 38,6±2,4 sec. (p<0.05),

indicating activation of hemostasis hypocoagulation.

Electrophoretic mobility of red blood cells in the examined groups of patients was

1,06±0,017 mkm×c^-1×V^-1 before UVBM and 1,1±0,016 mkm×c^-1×V^-1 after UVBM (p<0.05).

It shows a positive impact of UVBM on the physicochemical properties of the membranes.

Before UVBM the ejection fraction of patients was 59,3±4,3%, the stroke volume was

73,1±7,2 ml. After UVBM the ejection fraction amounted to 69,8±7,2% (p<0.05)

and the stroke volume – to 91,5±7,5 ml (p<0.05).

Conclusion

The efficacy of including UVBM into complex therapy of patients with ACS reveals

that therapeutic doses of ultraviolet (254 nm) radiation have a positive effect on the

oxygen metabolism and hemostasis in the body, increase the electrophoretic mobility of red

blood cells, improve functional parameters of the left ventricle.