A Case of Massive Ascites Occuring in a Pregnant Patient Given IVIG Infusion

Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies in the blood directed against a person’s own tissues leading to clotting and thrombosis. In pregnancy APS can cause complications such as preeclampsia, thrombosis, autoimmune thrombocytopenia, fetal growth restriction and fetal loss. One of the modalities used in immune therapy for pregnant patients with recurrent pregnancy losses secondary to APS is Intravenous Immunoglobulin (IVIg) infusion.

Here we present a case of an adverse event to IVIg presenting 3 days after infusion of IVIg as massive ascites in a 29 year old patient, 29 weeks age of gestation with preeclampsia and partial HELLP syndrome.