Methodology of the C(sp 2 )-Н Bond Functionalization in the Synthesis of Novel Imidazole Derivatives

Timofey Moseev tmoseev@yahoo.com ¹ Mikhail Varaksin ^1,2 Oleg Chupakhin ^1,2 Valery Charushin ^1,2

¹Department of Organic and Biomolecular Chemistry, Ural Federal University, Ekaterinburg
²Laboratory of Heterocyclic Compounds, Institute of Organic Synthesis, Ekaterinburg

The C(sp²)-H Functionalization methodology is known to be an atom- and stage-efficient synthetic approach for the synthesis of novel imidazole derivatives. It has been found that cyclic aldonitrones do react with both azoles (i,ii) and azines (iii-v) to give the novel heterocyclic systems in good yields.^1-3

The synthesized imidazole derivatives are of interest as promising polymer stabilizers, free radical trapping agents, biologically active compounds, and nitroxide radical precursors.

Varaksin, M.V., Utepova I.A., Chupakhin O.N., Charushin V.N. J. Org. Chem., 2012, 77, 9087.
Varaksin, M.V., Utepova I.A., Chupakhin. Chem. Heterocycl. Comp., 2012, 48, 1213.
Varaksin, M.V., Utepova I.A., Chupakhin O.N., Charushin V.N. Tetrahedron, 2015, 71, 7077.

The study was supported by the Russian Science Foundation (Project № 14-13-01177) and the Russian Foundation for Basic Research (Project № 16-03-00958)

Methodology of the C(sp2)-Н Bond Functionalization in the Synthesis of Novel Imidazole Derivatives

Methodology of the C(sp²)-Н Bond Functionalization in the Synthesis of Novel Imidazole Derivatives