Erythema Multiforme (EM) is an immune-mediated reaction presenting as acrofacial target lesions. Most studies utilize the outdated classification which includes EM, Steven Johnson syndrome and Toxic Epidermal Necrolysis as related entities. We describe epidemiological, etiological, clinical, laboratory and treatment characteristics of pediatric EM. This is a retrospective single-center study, held between 2000-2013. Of 119 children given an EM diagnosis, only 30 met clinical criteria and were included in this study. Most misdiagnosed cases were nonspecific eruptions and urticaria multiforme. Mean age was 11.3 years. 50% had mucosal involvement. An etiology was observed in half of the patients. 70% of patients were admitted, 46.7% were treated with systemic steroids. 16.6% had recurrent EM. The most common infectious agent associated with EM in this study was Mycoplasma pneumonia, association with Herpes Simplex Virus was not observed. Despite being a benign, self-limiting condition, children were over-treated in terms of hospitalization and therapy.
