Objective: Prenatal corticosteroids were shown to reduce the respiratory complication in late preterm infants. Our objective was to determine if early inhaled corticosteroids could alleviate the respiratory distress and morbidity in late preterm and term neonates with transient tachypnea of the newborn (TTN).
Design: Double-blind, randomized placebo-controlled, multicenter pilot study. Infants born at >34 weeks gestational age with TTN at 4 hours of age were randomized to two doses, 12 hours apart, of inhaled Budesonide 1000 µg/dose or placebo within 6 hours from delivery. Analysis was done by intention to treat.
Results: The study (n=24) and control (n=25) groups were comparable in birth characteristics (gestational age: 36.8+1.9 vs 36.4+1.8 weeks) and clinical condition at the time of recruitment (vital signs, clinical score, ventilation support, and blood gases). There was no difference between the study and control groups in clinical score (based on grunting, retractions, ala nasi and, respiratory rate) at recruitment and at 12, 24 and 48 hours after the first inhalation (4.3+1.6 vs. 4.1+2; 1.9+1.8 vs. 1.5+1.7; 1.1+1.4 vs. 1.3+1.6; 0.5+0.8 vs. 0.6+1.0; respectively). Respiratory support at each time point, time to spontaneous unsupported breathing (67.4+74.1 vs. 75.2+95.2 hours), time to full feeds (86.7+68.7 vs. 84.3+66.6 hours) and length of stay (9.9+5.5 vs. 12.4+8.0 days) did not differ between the groups. We did not detect any side effects.
Conclusions: Our study was unable to detect a beneficial effect of early administration of inhaled steroids on the clinical course of TTN in late preterm and term infants.
