Introduction: Nephrotic syndrome (NS) is associated with a hypercoagulable state due to changes in the fibrinolytic system`.thrombocytosis heigh fibrinogen the increase in the plasma levels of fibrinogen and coagulation factors V. The incidence of thromboembolic complications in children with NS varies between 2 and 5%.. can be venous or arterial
Case Report: A3 years male child with 6-month history of NS treated with prednisone alternate day was admitted to the pediatric emergency complain of vomiting and diarrhea On physical examination, the child exhibited pallor, dehydration, , , edema ++/4+, and no signs of meningeal irritation. Venous access was obtained,and hydration with saline innitiateted Laboratory exams revealed leukocytosis (global leukocytes:22000), hypoalbuminemia (1.8/dL (;renal function electrolyte all normal Urinalysis +3protein no hematuria. The day laterhe suffered from headache and strabismus. imaging was conducted, which revealed superior sagittal sinus and transverse sinus thrombosis)., treatment for venous thrombosis (CVT) began with a continuous infusion of intravenous heparin.
Conclusion: NS is a known risk factor for venous thromboembolism because of the loss of coagulation factors and acute intravascular volume depletion during this phase of the disease.Cerebral venous thrombosis should be considered pediatrics with nephrotic syndrome who presents with headech neurological symptoms. Importantly, early clinical suspicion is correlated with a more favorable outcomes.
