BIO-INSPIRED HYDROCARBON OXIDATIONS BY NONHEME IRON CATALYSTS

Lawrence Que
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota

Inspired by the versatile oxidation chemistry catalyzed by nonheme iron enzymes, we have been investigating the iron-catalyzed oxidations of hydrocarbons. Highly stereoselective cis-dihydroxylation of olefins have been observed with the use of nonheme iron(II) complexes with H2O2 as oxidant. Insights into the catalytic mechanism have been obtained from a combination of product distribution studies, 18O labeling experiments, and kinetic analysis as well as DFT calculations. These results implicate a high-valent iron-based oxidant. Hydrocarbon oxidation can also be observed for iron complexes supported by tris(pyrazolyl)borate ligands that activate O2. A high-valent iron-based oxidant is also postulated for these reactions, which exhibit shape selectivity. The unusual shape selectivity observed suggests that substrate recognition can be elicited even in a biomimetic complex of relatively simple design.









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