Aim: study of comparative efficacy of Coryzalia in children with IR and AR.
The study included 74 children from 3 to 15 years (8,4±2,5). The patients were divided into 3 groups and 4 subgroups – 34 with IR (1), 30 with AR (2), 10 with IR+AR (3). 1A – monotherapy-16 children with IR, 1B–combined with vasoconstictive medication – 18 with IR; 2A – monotherapy-15 with AR, 2B – combined with antihistamines – 15 with AR. Coryzalia was prescribed in 1 tablet every 1 or 2 hour during the day. The treatment lasted from 5 (IR) to 14 (AR) days.
We also estimated allergic anamnesis, computerized bronсhophonography (CDPhG), ciliary potency: saccharin test, brush biopsy. Nasal stuffiness during night and day, nasal cavity discharge, sneezing, cough were estimated from 0 to 4 points.
Results: All clinical symptoms are improvement in 82% of patients with IR, 67% with AR, 50% with IR and AR. In therapy IR there was improvement of CDPhG in a low frequency range in group 1A from 120,1 ± 10,5 to 113,4 ± 19,29 (р<0,05); and in 1B from 90,6± 30,5 to 66,55± 10,4 (p<0,001); as long as in a high frequency range in 1A from 0,15± 0,23 to 0,08± 0,03 (р<0,05); in 1B from 0,16 ± 0,2 to 0,1 ± 0,1 (р<0,03). In therapy of AR in 2A from 147,8 ± 12,5 to 116,6 ± 9,29 (р<0,001); in 2B from 200,7 ± 10,5 to 105,6 ± 8,11 (р<0,015); in a high frequency range in 2A from 0,22 ± 0,23 to 0,15 ± 0,03 (р<0,05); in 2B from 0,34 ± 0,23 to 0,196 ± 0,03 (р<0,01). In children with IR the time of saccharin test was reduced from 22,33±12,1 to 12,5±7,4 min (normally 8,8±4,9); with AR from 19,0±11,2 min to 14,1±7,3.
CDPhG can be used to cure both IR and AR. Coryzalia improves clinical effect of treatment and quality of life of patients.