The Effect of Controlled Ovarian Hyperstimulation On Anti-Mullerian Hormone and Inhbin B Levels in Obese and Non-Obese Women
2Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
3Sheba Medical Center, Institute of Endocrinology, Tel Hashomer, Ramat-Gan, Sackler School of Medicine, Tel Aviv University, Tel Aviv
Introduction: Obesity has a negative effect on assisted reproductive technology outcomes; however, the exact molecular mechanism for this deleterious effect is not clear. Previous studies found a negative association between BMI and basal serum levels of inhibin B and AMH.
Aim To determine the effect of controlled ovarian hyperstimulation (COH) on AMH and inhibin B levels in obese individuals.
Materials and Methods This prospective longitudinal study was conducted from April 2014 through August 2014. 27 patients undergoing IVF, were enrolled. They were grouped according to BMI 2 or ≥30 kg/m2. Inhibin B and AMH levels were measured before ovarian stimulation (T0) and on hCG administration day (T1).
Results There was a trend toward higher AMH levels on T0 in patients with BMI ≥30 compared to BMI
Conclusion: AMH and inhibin B Levels changes during COH were similar in obese patients in comparison to non-obese patients; thus, adjustment for BMI is not required when testing AMH and inhibin B levels.
Powered by Eventact EMS