Endothelial Dysfunction Corection in the Teenagers with Primary Artherial Hypertension by Essential Phospholipids

Backgruond: Formation of arterial hypertension (PAH) is associated not only with the state of vascular tone, but it is associated with endothelial relaxation disorders. We investigated morphological features of PAH duration with endothelial dysfunction (ED) in the children by used optimized treatment

Material and methods: The 80 children (15-17 years) diagnosed with PAH ED were examined and divided into two groups: 1 group, n=40 patients, used basic treatment), group 2, n =40 patients, who used optimized treatment(with the lecithin inclusion to the basic treatment in the age dose).

Results: Problems with homeostasis were found in the case of adolescents with PAH and ED in the endogenous antioxidant system, the level of intensity of child`s
organism inflammatory response . Based on cytokine profile tests and the antibody production of child`s organism, the morphofunctional characteristics of the heart and blood vessels, the clinical and pathogenetic significance of ED of adolescents with PAH were confirmed. The efficiency of optimized treatment has been proved in the case of adolescents with PAH and ED when they used basic treatment with the inclusion of essential phospholipids(lecithin).

Conclusion: Levels of aortic stiffness index tended to decrease, as confirmed by improving hemodynamic parameters. Value Ve / Va had direction to increase. Vessel vasoconstriction was significantly decreased during the reactive hyperemia test, but the degree of vasodilation was varied depending from the method of treatment. KIM thickness decreased to 1.12 times in the children with optimized treatment along with a rate decrease in the 2 times of the endothelial cell desquamation.