Inflammatory Response in Chronic Pancreatitis Patients with Exocrine Insufficiency and Ways Correction

Background: Chronic pancreatitis is a progressive disease which characterized by ongoing inflammation of the pancreas and linked to the exocrine insufficiency interdependence. Symptoms and complications vary from person to person, so treatments are tailored to each person`s needs.

Material and methods: Severity of inflammatory and inflammatory and destructive changes in the pancreas in the patients we have studied according to our date (general clinical parameters and laboratory examinations). Patients with cystic fibrosis were excluded we measured the levels of pro- and anti-inflammatory interleukins before and at the end of inpatient treatment. We have selected 87 patients with chronic pancreatitis pain and with exocrine insufficiency who were treated in the gastroenterology department of transcarpathian region hospital in the 2013-2015 yy. To achieve this goal results the levels of pro- and anti-inflammatory interleukins before treatment were significantly higher than normal. There are- TNF, IL-6, IL-4 and IL-10. But after treatment pro-inflammatory interleukins were decreased more significantly than inflammatory. Thus, TNF and IL-6 levels had tendency to reference value. Level of anti-inflammatory IL-4 was decreased to reference value too. IL- 10 in study patients was moderately and significantly increased but was decreased significantly at the end of the 3rd week of treatment. Thus, the treatment was effective not only according to traditional subjective and objective examination data and were confirmed by changes in the levels of such sensitive indicators as pro- and anti-inflammatory interleukins with positive direction after treatment.

Conclusion: optimized treatment scheme using leds to the normalization and significant pathological change reduction of of the pro- and anti-inflammatory interleukins levels and as result - decrease of the severity of inflammatory changes in the pancreas.