Status of Vitamin D in Children and Adolescents with Celiac Disease
2Pediatrics, Russian Medical Academy of Continuing Postgraduate Education
3Technology of milk, North-Caucasian Federal University
Objective: was to analyze the status of vitamin D (VD) sufficiency in children and adolescents in the acute period of celiac disease (CD) and keeping a gluten-free diet (GFD).
Methods: 77 children with CD were examined: 29 (37.7%) boys and 48 (62.3%) girls aged 1 to 18 years, who were divided into three groups. The 1 included 22 (28.6%) children examined in the acute period of CD, the 2 included 37 (48.0%) patients keeping a GFD, and the 3 included 18 (23.4%) diet non-compliant patients. The control group included 14 healthy children.
Results: The status of VD sufficiency in children of the control group was within the normal range. The levels of 25(ОН)D in the patients with acute CD were 2.1 times lower (p<0.001) than in the healthy children. The content of calcidiol in the GFD-compliant children was 2.0 times lower (p<0.001), and in the non-compliant patients 2.4 times lower (p<0.001) than in the control group.
25(ОН)D levels in children with CD
|
Control group |
Acute period |
GFD |
||
|
Compliant patients ченин в дающий1500 МЕ) |
Non-compliant patients |
|||
|
Me [25Q-75Q] ng/ml |
44.8 [41.6 – 52.3] |
21.5 [12.4 – 31.2] |
22.6 [16.3 – 28.7] |
19.0 [13.3 – 28.5] |
|
Less than 10 ng/ml |
– |
2 (9.1%) |
1 (2.7%) |
2 (11.1%) |
|
10 – 20 ng/ml |
– |
7 (31.8%) |
14 (37.8%) |
8 (44.5%) |
|
20 – 30 ng/ml |
– |
7 (31.8%) |
15 (40.5%) |
5 (27.8%) |
|
More than 30 ng/ml |
14 (100%) |
6 (27.3%) |
7 (19.0%) |
3 (16.6%) |
Conclusions: The study of 25(ОН)D levels in blood serum indicated a low VD sufficiency in children and adolescents with CD. A tendency to the parameters improvement in the group of patients keeping a strict GFD was observed; however, even these patients failed to reach the normal calcidiol levels without additional nutritional supplementation. It is evident that children and adolescents with celiac disease need to be provided with cholecalciferol drugs all year round to significantly improve their status of VD sufficiency.
Powered by Eventact EMS