Complications of Pregnancy in Asthmatic Women and Development Allergy in their Infants I.I.Evsyukova D.O.Ott Research Institute of Obstetrics & Gynecology, St-Petersburg, Russia

Objective: to determine the role pathology of pregnancy of the asthmatic womans in development of their infant’s allergy.

Methods: The analysis clinical state during first year of life 86 full term newborns, which mothers had bronchial asthma (BA): mild BA (63)– I group, moderate and severe BA(23) – II group. All infants received only the maternal milk to 5-6 month of life. Results. 1. No associations were observed with current symptoms of BA during pregnancy and the newborn’s illness (IUGR), which was 38% in I and 39% in II groups. 2. The pathology of placenta were the main cause in development of allergy during first year of life. 36,5% women of I group had the chronic placental insufficient, 39,0% - pathologic immaturity of placenta and respectively 39,1%, 39,4% women of II group. 3. Having pathologic immaturity of placenta with chronic placental insufficient were associated with more earlier (during the first month of life 21,4% infants) and more significantly higher risk of allergy after 6 month of life: 64,2% against 30,0% (p<0,05) in infants which mothers hadn’t such complications.

Conclusion: The results suggest that pathology of the of placenta play the main role in alteration of functional activity antigen presenting cells of newborn’s immune system and explain the association between number of future risk of atopic disease.