A Systematic Review about S.pneumoniae Serotype Distribution in Children in Mainland of China

Aim: To evaluate the serotype distribution of S.pneumoniae in China, from which multi-centers survies were limited.

Methods: This review systematically reviewed the studies conducted among 2006 to 2015, with serotype data of S.pneumoniae isolates among children in China hinterland from the published literatures. Using Median (M) and Decile Range (D) to analyse the serotype proportion andl vaccine coverage rate.

Results: A total of 35 papers were collected for anlysis. Among non-invasive strains, the rates of serotypes were 19F ( 28.2%), 23F ( 12.2%), 19A ( 16.4%), 14 (8.0%), and 6B ( 4.9%) in north region; and in south region, the rates of serotypes were 19F ( 44.6%), 23F ( 9.2%), 19A ( 13.3%), 6B ( 8.1%), and 14 ( 6.0%). Among invasive strains, the rates of serotypes were 19A ( 23.8%), 19F ( 16.0%), 14 ( 17.2%), 23F ( 8.2%), and 6B ( 4.8%) in north region; and in south region, the rates of serotypes were 19F ( 24.5%), 19A ( 19.6%), 14 ( 18.2%), 6B ( 6.6%), and 23F ( 8.7%); while in multicenter, the rates of serotypes were 19F [ 21.2% (D: 17.7% - 27.0% )], 19A [ 23.5% (D: 11.6% - 32.0% )] , 23F [ 4.8% (D:2.5%-7.7%)], 14 [ 9.8% (D: 5.9% - 17.4 )].

Conclusions: In hinterland of China, the prevailing serotypes in children under 14 years old were serotype 19F, 19A, 23F, 14 and 6B. The serotype coverage rate of PCV13 was higher than PCV10 due to the high rate of serotype 19A.