HIV Related Kidney Diseases

Introduction: Since the earliest description of HIV infection, renal involvement were reported. Renal disorders are encountered at all stages of HIV infection, and they range from the imbalances commonly seen in hospitalized patients to end-stage renal disease (ESRD). We refer an estimated 10,000 children infected in Romania, from1987-1990. children Cohort.

Objectives: study prevalence, gender, viral load, renal pathologies, mortality of HIV patients with renal manifestations in western Romania.

Material: The children admitted in Timisoara children hospital between 1994-2015, from a total patients with HIV: 640 and those with renal manifestations (albuminuria, malformations, ESDR). Methods for detection a renal disorder: Addis count, Albuminuria, Urine culture, 24 urine collection, Serum creatinine and Creatinine clearance.

Results: We analise age of the onset of HIV infection, type of kidney involvement, in conection with antiretroviral therapy and modality of transmission, stage at the monent of presentation in hospital, Viral load and CD4+ count, and renal parameters. Kidney involvement was noticed in 21% of the cases (65% Females , 35% Males). 90% acquired the disease from parenteral route of a blood product and syringe reuse. 26% deaths from135 with kidney involvement (73% died between the years 1994-1999). UTI among deaths was the most common pathology 24 out of the 35 mortal cases.

Conclusions: 90% acquired the virus via nosocomial way of transmission mainly by parenteral route of a blood product and syringe reuse. From eight different types of renal involvement the urinary tract infection was by far the most common involvement (E. coli 61%). 63% of the patients were stage C as per CDC staging, with C1 and C3 being the most prevalent. Mortality rate of 26%, much higher than it is displayed in another studies. Albuminuria was present within deaths in (53%) of the cases, in living patients (15%) of the patients.