Changes in Complete Blood Counts in Patients with Ischemic Heart Disease and Instent Restenosis

Objectives: To analyze and compare neutrophil/lymphocyte, platelet/lymphocyte, monocyte to high-density lipoprotein ratios in the peripheral blood of patients with in-stent restenosis and with no in-stent restenosis.
Methods: This study is based on the data analysis of one hundred of 45-74 years old patients who have been hospitalized with ischemic heart disease. We included patients with symptoms of angina pectoris, specifically unstable angina, ST elevation MI, non-ST elevation MI and postinfarction cardiosclerosis. All patients have undergone CT coronarography twice and based on the results of their second coronarography were equally divided into two groups. The first group consisted of 50 patients with in-stent restenosis and the second of 50 patients without in-stent restenosis. Based on the descriptive analysis, the patients in both groups did not differ by age, gender or medical conditions. Every patient had a complete blood count work up particularly absolute numbers of neutrophils, lymphocytes, platelets and level of high-density lipoprotein tests done. Based on the above mentioned data, the following list of ratios have been calculated: neutrophil/lymphocyte ratio, platelet-lymphocyte ratio and monocyte to high-density lipoprotein ratio.
Results: The results of this study suggest that there is a statistically significant difference in neutrophil/lymphocyte ratio in patients with in-stent restenosis 2.68±0.31comapared to the other group of patients with no restenosis 1.77±0.13 (p≤ 0.01). Similar statistically significant difference was observed in platelet/lymphocyte ratio within patients who experienced in-stent restenosis 134.17±9.9 compared to those with no in-stent restenosis 112.45±8.69 (p≤0,05). There was no statistically significant difference in monocyte to high-density lipoprotein ratio among groups with in-stent restenosis and with no in-stent restenosis.
Conclusions: There is an association between in-stent restenosis in patients with ischemic heard disease and the results of complete blood count as demonstrated by increased neutrophil/lymphocyte and platelet/lymphocyte ratios.