Serum Aldosterone and Coronary Artery Disease

Background and objective: The role of aldosterone is well studied in the patients with heart failure (HF) and acute myocardial infarction (MI). But little data is available about the level of aldosterone in patients with coronary artery disease (CAD). This study was designed to evaluate whether this relation is exist or not.
Methods: The study population consisted of 94 subjects aged 40-69 years who were referred to heart center of Mazandaran. The subjects were classified as CAD cases and controls according to the results of coronary angiography. The patients with acute MI, HF, hypertension, diabetes, inflammation and who used angiotensin converting enzyme inhibitors in recent two weeks were not included in the study.
Results: Forty nine patients had at least more the 50% stenosis on one of epicardial coronary and the others were normal coronary. Serum aldosterone was found to be 161.6±1851pg/L in patients with coronary artery disease (CAD) and 123.8±68.3 pg/L in patients with normal coronary (P=0.201).
Conclusion: The results demonstrate that the level of aldosterone had not significant differences between the patients with and without CAD.