The Effect of Hypothermia on Irisin Concentration in Coronary Bypass Surgery Patients

Coronary bypass surgery has a process of cooling the patient. As known there is a relation between hypothermia and irisin, which is responsible for releasing heat. It was therefore examined the effects of hypothermia on blood irisin concentration in coronary bypass surgery patients. Biological samples (15 samples for each time frame) collected before induction (T1), before bypass (T2), before (T3) and after (T4) removing the cross-clamp, upon admission to intensive care (T5), and at the post-operative 24 (T6) and 72 (T7). Irisin levels were analyzed by using ELISA. Irisin concentration significantly increased gradually from the time of induction to the removal of the cross clamp. After the patient was started to be warmed, irisin starts to decrease gradually and were restored to normal levels on the second and third post-operative days. These data indicate that hypothermia induces irisin, possibly through controlling body temperature via releasing heat, and that the irisin appears to be decrease as hypothermia diminishes.