Polimorfism C825t Gene Beta-3-Subunit of G Protein and Traditional Risk Factors Among Young And Middle-Age Women with Coronary Artery Disease

Objective: to evaluate the prevalence of traditional and certain gene factors in young and middle age women with coronary artery disease (CAD). Detection of allelic variants of the gene GNB3 S825T was conducted in 121 young and middle age (52,0 ± 0,6 years) women with CAD. Reproductive function (RF) was preserved in 49 (40%) women. Arterial hypertension (AH) met in 109 (90%), obesity - in 65 (54%) patients. In the group with preserved RF 43 (88%) women had AH, 28 (57%) of women had obesity. Among women in menopause AH was observed in 66 (92%) patients and obesity in 37 (51%) (p> 0,05). There was significant increase in the frequency of gene polymorphism С825T GNB3 in hetero- or homozygous state in the presence of a history of AH: 50% and 50% for genotypes CC and CT + TT, respectively. Among AH women and patients without AH - 83% and 17% for genotypes CC and CT + TT, respectively (p <0.05). In women with AH - 825T allele carriers of the gene GNB3 experienced significantly higher values of systolic (169 ± 2 and 179 ± 1 mm Hg for the CC and CT + TT, respectively, p <0.01) and diastolic blood pressure (104 ± 2 and 112 ± 1 mm Hg for the genotypes CC and CT + TT, respectively, p <0.001). Among patients in menopause obesity was more common in carriers of CT and TT - 60% vs. CC - 34%.