Germinated asexual spores of Neurospora crassa detect the presence of genetically identical partners, communicate with and grow towards them, and fuse to form a syncytium. We previously found that genetically distinct isolates from the same population fall into exclusive communication groups (CGs) and we used bulk segregant analysis to identify a single locus containing one to three paralogous genes associated with CG. Although the two genes at the CG locus in our lab strain are not essential for self-communication, we demonstrated that they are necessary and sufficient to specify CG (Heller et al. 2016). We named these genes determinant of communication (doc) 1 and 2. doc-1 and doc-2 have no characterized homologs, nor have we identified any protein domains within them. We developed a flow cytometry-based communcation quantification system to assay doc mutants, but the mechanism by which the doc genes control CG remains elusive.