Rapid, Modular, Sterodivergent and Catalytic Construction of Contiguous Elements in Acyclic Series from Alkynes

Previous studies in our group showed that strained rings could be easily functionalized and ring-opened to access acyclic molecular frameworks bearing stereocontrolled quaternary centers.¹ Following those pioneering works and inspired by the concept of metal-walk,² we investigated the behaviour of 2-vinylcyclopropylmethanol derivatives in Heck reactions (Scheme 1). We are pleased to report a highly modular and diastereoselective approach that enabled the access to most stereoisomers, in only three catalytic steps from easily accessible starting materials.³

Scheme 1: Rapid and modular access to complex acyclic systems

References:

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