Synthesis of Fluorescent Water Soluble Calixarenes and there Chemosensory Applications

Water soluble calixarene attracted considerable attention in supramolecular chemistry because of its hydrophobic cavity which allows a deeper understanding of host-guest recognition process in a solvent where most biological process occurs.¹ In this work, we have synthesized water soluble calixarene by introducing sulphonic group to the upper rim of calixarene.² Replacement of oxygen atom from the lower rim of calixarene with triple bond by selective metal catalyzed reaction provide extended conjugation system.³ These fluorescent water soluble calixarene scaffolds utilized in a chemosensory application for the detection of biological molecules.

References:

1. Gutsche, C. D. Calixarenes, Royal Society of Chemistry, Cambridge, 1989.
2. Shinkai, S.; Araki, K.; Tsubaki, T.; Arimura, R.; Manabe, O. Chem. Soc., Perkin Trans. 1 1987, 2297-2299.
3. Molad, A.; Goldberg, I.; Vigalok, A. Am. Chem. Soc. 2012, 134, 7290-7292.