Novel Indoline Derivatives are Effective in the Treatment of Acute Pancreatitis

In the course of investigations on our novel idoline derivatives, which have been found to display potent anti-inflammatory and antioxidant activities, previously we described their activity against acute liver failure. Herein we report promising activity for the treatment of pancreatitis. Acute pancreatitis was induced in male Balb/c mice by ip injection of cerulein (50 μg/kg), 4x1/h. Vehicle or compounds, indoline derivative AN1297 or resolvin (positive control), dissolved in saline were injected sc once, 30 min after 1^st cerulein injection. The primary indication of efficacy of AN1297 against acute pancreatitis was the reduction in serum amylase at doses of 1 and 2 mg/kg by 73% and 86%. AN1297 (2 mg/kg) was also very effective in reducing all other indicators of inflammation, TNF-α, nitrotyrosine (NT), neutrophil infiltration, pancreatic damage, such as edema and necrosis, more effectively that the control drug resolvin 1 mg/kg.