Nuphar Vinegrad1, Maya Atar2, Dr. Lena Npvack1 and Prof` Rafael Gorodischer1,3,,4
Introduction.
Exposure to acid suppressor medications (histamine2-receptor-blockers H2 Bs- and proton pump inhibitors-PPIs) was reported to be associated with neonatal infections. The purpose of the present study was to learn whether maternal use of these medications represents a risk factor for infections in neonates.
Methods.
In a retrospective cohort study we enrolled infants born at the Soroka Medical Center, between 1998 and 2012 and their mothers, members of "Clalit Health Services". The exposed group included all infants whose mothers purchased any H2 B or PPI during their pregnancy. Infection was defined by hospitalization due to bacterial infections. Computerized medications database was linked with hospital records of mothers and their infants.
Results.
Of eligibly mothers 1182 (6.2%) consumed H2 Bs or PPIs during pregnancy and/or during the first month following delivery We found no association between prenatal exposure to H2Bs or PPIs and neonatal infections (OR=1.536, p=0.645). However, maternal consumption of H2 Bs or PPIs during the first month following delivery was associated with a greater risk of neonatal bacterial infections (OR=5.697, p=0.003). Similar results were obtained for maternal consumption of PPIs alone during the first month of infants` life (OR=7.166, p=0.001).
Conclusions.
This study indicates a potential risk of maternal use of acid suppression medications during the first month of the infant`s life. A possible explanation will be discussed.
