Mucoadhesive Drug Carriers

The mucosa gel layer is a secretion lining organs which are exposed to the outer surface of the body yet are not covered with skin. Transmucosal drug delivery involves transport of therapeutic agents through this layer. This method of delivery offers several potential benefits over oral drug administration including relatively rapid uptake of a drug into the systemic circulation and enhanced bioavailability. Mucoadhesion, i.e. adhesion of the drug carrier to the mucosa, enhances the performance of transmucosal delivery systems by providing extended residence time of the drug at the site of application. In my talk I will describe new approaches based on modification of polymers as a way to enhance mucoadhesion. Specifically, Michael type addition reactions are used to covalently attach polymers bearing unsaturated side groups to the mucus. Our studies involved synthesizing of novel biomaterials, and extensive characterization of their properties. We demonstrated a significant improve in adhesion, and lack of toxicity. Applications in the field of oral cancer treatment will be emphasized.