The Impact of 12 Week Exercise Training Program on Circulating Soluble-Klotho in Coronary Artery Disease Patients - The 65th Annual Conference of the Israel Heart Society & The Israel Society of Cardiothoracic Surgery, 24-25 April 2018

Evgeny Radzishevsky Department of Cardiology, Bnai Zion Medical Center, Haifa, Israel Liran Bradichansky Department of Cardiology, Bnai Zion Medical Center, Haifa, Israel Alon Tanchilevitch Department of Cardiology, Bnai Zion Medical Center, Haifa, Israel Ehud Goldhammer Department of Cardiology, Bnai Zion Medical Center, Haifa, Israel Irit Maor Department of Cardiology, Bnai Zion Medical Center, Haifa, Israel Uri Rosenschein Department of Cardiology, Bnai Zion Medical Center, Haifa, Israel MO Saghiv Department of Exercise Physiology, Harold C. Miller Center, University of Mary, Bismarck, USA

Background: The klotho gene was identified as an age-suppressing gene in mice that extends life span when overexpressed. It is a membrane-based circulating protein that regulate cell metabolism and activity of fibroblast growth factors (FGFs). Higher plasma circulating Klotho levels correlates with reduced cardiovascular risk. Aerobic exercise reduces the risk of cardiovascular events and mortality in patients with proven coronary artery disease (CAD), thus, S-Klotho serum levels were assessed in order to find out whether exercise can modulate its activity.

Purpose: to assess the impact of 12 weeks exercise training on S-Klotho.
Methods: S-Klotho serum levels were assessed in 2 groups: gr. A = 41 CAD patients, age 59.6 years ± 2.2 sd, all with a recent (< 45 days) cardiovascular events or intervention who participated in a 12 weeks supervised aerobic exercise, and gr. B, a control group consisting of 17 CAD age matched patients who continued their usual treatment and lifestyle. Assessment was done twice, prior to exercise program initiation and at the end of 12 weeks intervention. S-Klotho levels were analyzed using an enzyme linked immunosorbent assay kit (IBL, Immuno-Biological Laboratories Co., Japan).

Results: S-Klotho levels did not differ at baseline between the two groups, 770.49pg/ml +/- 202.20 sd and 727.54pg/ml +/- 207.83 sd respectively, p= ns, while a significant difference noticed following exercise intervention, 863.39 pg/ml +/- 213.66 sd in gr. A compared to 677.71pg/ml +/- 167.46 sd in gr. B, p
Conclusions: Aerobic exercise may modulate S-Klotho activity, thus conferring a possible mechanism for the enhanced survival of CAD patients participating in an exercise based cardiac rehabilitation program.