Effect of Catheter Denervation of Renal Arteries on Intracardiac Hemodynamics and Quality of Life in Patients with Chronic Heart Failure

Introduction: Catheter denervation of the renal arteries (CDRA) is an innovative method of treatment in patients with chronic heart failure (CHF). It allows controlling the effects of the sympathetic nervous system. The principle of the method is based on the use of high-frequency current, which destroys the sympathetic nerves localized in the renal arteries adventitia.

Aim: to investigate the effect of CDRA on intracardiac dynamics and quality of life (QOL) in patients with CHF for 12 months of follow-up.

Material and methods: The study included 25 patients with CHF NYHA III. At base, in 6 and 12 months after DPA patients underwent transthoracic echocardiography in to assess intracardiac hemodynamics. The quality of life was assessed using the Minnesota Questionnaire Life with Heart Failure.

Results: Changes in the parameters of intracardiac hemodynamics in patients at baseline in 6 and 12 months after CDRA demonstrates Table 1.

An improvement in some echocardiographic parameters was accompanied by an improvement in the clinical status of patients: a decrease in dyspnea, an increase in exercise tolerance and the level of QOL after the CDRA. If initially the median values of the QOL were 57 (44, 61) points, in 6 months after CDRA it became 47 (32; 55) points, 12 months - 42 (24, 44) points.

Conclusions: In 12 months after CDRA the values of EDV significantly decreased. The tendency of a decrease in EDD and an increase in LVEF was revealed. Functional class of CHF decreased in 75% of patients that was accompanied by improvement of patients’ QOL.