Cardiovascular Manifestation of Hematological Malignancy

Background: Myeloproliferative disorders (MPDs) are defined as neoplastic diseases, that involved a proliferation of the myeloid stem cells or it`s derivate. Bleeding and thrombosis are the primary causes of morbidity and mortality in patients with chronic MPDs. According to the literature, the cardiovascular is involved in 4-21% of the cases and it`s including; Acute Ischemic Coronary Artery Disease, Valvular and Pericardial involvement.

Our aim is to raise awareness, to the possible cardiovascular involvement of hematological malignancies.

Methods: We present 2 women, who hospitalized in our department in the last year. The first case, a 63 years old woman, known with Primary Myelofibrosis, accepted with palpitation, and with the diagnosis a supraventricular tachycardia (SVT) and Non-ST elevation Myocardial Infarction (NSTEMI). The second patient, an 84 years old woman, was accepted with dyspnea, a huge heart silhouette on chest X-ray and malignant pericardial effusion. The patient was treated with repeated pericardiocentesis. Cytological diagnosis was of a rare Non-Hodgkin`s Lymphoma known as Primary Effusion Lymphoma.

Conclusion: In Summary, the myeloproliferative disease was diagnosed as a contributor to the severity of the disease, and as a presenting signs, in the second case.

We believe that healthcare physicians, especially cardiologists, should take those diseases (MPDs/Lymphoma`s) in mind.