Sustainable Catalysis Based on Earth-abundant Pincer Catalysts Design

Subrata Chakraborty subrata.chakraborty@weizmann.ac.il Urs Gellrich Gregory Leitus Yael Diskin-Posner Liat Avram Uttam Kumar Das Yehoshoa Ben-David David Milstein
Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel

Abstract: Concerns in view of sustainability, which is of imminent necessity today, the development of sustainable, highly efficient, environmentally benign and selective catalytic reactions generating no waste and require little energy is one of the main fundamental research goals of today’s chemistry. Traditionally, second- and third-row transition metals have been extensively exploited in organometallic chemistry, especially in catalytic applications. However, there are significant and growing issues associated with the longer-term use of these metals. The first of these is cost and supply and a second issue associated with the use of platinum-group metals is their relatively high toxicity. Therefore low cost, ready availability, comparatively low toxicity, and greater sustainability are all factors lead to a major renaissance in the study of the homogeneous catalysis of Earth-abundant metals, particularly first row base-metals (Fe, Co, Ni, Mn, Cr) over the past few years. In this respect, catalysis based on iron and manganese complexes is highly desirable. Successful application of iron and manganese based PNP pincer complexes in various sustainable hydrogenation and dehydrogenation reactions were accomplished. Selective homogeneous hydrogenation of nitriles to primary and secondary imines, hydrogenative cross-coupling of nitriles and amines to cross secondary aldimines,[1-3] in addition to unprecedented N-formylation reactions of amine using methanol and dehydrogenative coupling of alcohols and nitriles will be presented.[4-5]

References:

  1. Chakraborty, G. Leitus, D. Milstein, Chem. Commun., 2016, 52, 1812-1815.
  2. Chakraborty, D. Milstein, ACS Catalysis, 2017, 7, 3968-3972.
  3. Chakraborty, G. Leitus, D. Milstein, Angew. Chem. Int. Ed., 2017, 56, 2074-2078
  4. Chakraborty, U. Gellrich, Y. Diskin-Poschner, G. Leitus, L. Avram, D. Milstein, Angew. Chem. Int. Ed., 2017, 56, 4229-4233.
  5. Chakraborty, U.K. Das, Yehoshoa Ben-David, D. Milstein, J. Am. Chem. Soc., 2017, 139, 11710-11713.








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