Is There Any Additional Benefit in Adjusting Fet Timing According to the Era Test
AWARD NOMINEE

Introduction: Recently, a new technique developed from the transition to microarray molecular analysis using a customised array to identify markers of endometrial receptivity, has been offered. The endometrial receptivity array (ERA) is based on analysis of expression of 238 genes that are thought to be involved in the endometrial implantation, enabling the determination of a personalized window of implantation

Aim: The aim of the present study was to examine whether adjusting the personalized window of implantation according to the ERA test increases pregnancy rate.

Methods: A single-center retrospective cohort study, including 53 consecutive good prognosis patients admitted to our IVF unit, for a mock cycle prior their frozen day-5 embryo (blastocyst) transfer cycle that included an endometrial biopsy for both the ERA test and histological assessment by Noyes criteria (study group).

Results: During the study period, 503 patients (control group) underwent FET cycles without performing the ERA testing and 41 patients following an ERA test. There were no in-between group differences in patients’ age, number of previous transfers, endometrial thickness, number of transferred embryos and ongoing pregnancy rates (35.2% vs. 39%, respectively). While comparing the results on the ERA with the Noyes criteria, only 47% of the results were comparable between the two groups, and out of the 19 receptive samples, according to the ERA test, only 6 (31.6%) were receptive according to Noyes criteria. Conclusions: Performing the ERA test prior to the FET doesn’t seem to improve the ongoing pregnancy rate in good prognosis patients.