Alpha One – Antitrypsin Levels in the Perilymph of Patients Undergoing Cochlear Implant
2Otorhinolaryngology Department, Head and Neck Surgery, Hanover Medical University
Background: Trypsin plays a role in the inflammatory process. It affects the hair cells and the collagen fibrils in the inner ear. Alpha one antitrypsin is the main inhibitor of trypsin activity. Previous studies show low perilymph Level of alpha one antitrypsin in the perilymph of otosclerosis involving the cochlea.
Objectives: To evaluate α1-antitrypsin Level in the perilymph of patients undergoing cochlear implant (CI), and its relation to the etiology and severity of hearing loss.
Subjects and Method: Retrospective study including patients undergoing CI surgery in Tertiary care university hospital – MHH Germany. During CI, 1.5 cc of perilymphatic fluid is collected with a micropipette. Α1-antitrypsin levels of the Perilymph was measured and the audiological history and current parameters were obtained.
Results: perilymph analysis was performed from 41 patients, 8 of them had moderate hearings loss (PTA 70 dB ) 17 severe Hearing loss (PTA 70-90 dB) and 16 profound Hearing loss (PTA>90 dB). Mean level of Α1-antitrypsin in the perilymph in the moderate group was 3.64X106 U ±2.1X106vs. 3.5 X106 ±1.2 6 in the severe hearing loss group (p=0.81) and 2.4X106 ±1.1x106 the profound hearings loss group (p=0.04) ,comparing the level in the severe group versus the profound group the difference was statistically significant (p=0.04)
In 8 patients the etiology was congenital deafness, Average level of Α1-antitrypsin in the perilymph was 2.75X106 U ±1.4X106 compared with 3.20X6 ±1.5X6 in other aetiologies’ (p =0.40)
Conclusion: Α1-antitrypsin in the perilymph seems to play a role in the ethology of the hearing loss and may be to the severity of the hearing loss.
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