Clinical Outcome of Fresh Cycle with Presence of Degenerative Oocyte at Oocyte Pick-Up

Introduction: Degenerative oocyte (DEG) after ICSI could reflect poor oocyte quality and affect subsequent embryo development and were commonly derived from women with significantly higher estradiol, higher number of mature oocyte. Less fertilization rate TOP quality embryo were correlated to presence of DEG after ICSI.

Aim: How does the presence of DEG oocyte at OPU impact the total cohort quality, embryo morphokinetics evaluated by Time-laps incubator and IVF outcome?

Material and Methods: Retrospective cohort study. Records of all patients that their embryos were cultured in a time-laps incubator were evaluated from January 1, 2016 until December 31, 2016.

Results: A total of 153 cycles, 540 normal oocyte were derived from cycles in which at least one DEG oocyte was observed at the time of OPU. 1596 oocyte were compared as a controlled group from OPU with no DEG. We found that both group were comparable in term of patient`s age and BMI. In the DEG group significantly more oocyte were collected per patient and more mature oocyte were achieved (15.2±8.1 vs. 11.5±6.5, P=0.0001 and 10.0±6.7 vs. 8.5±4.6, P=0.001; respectively). No differences were found in fertilization rate and the morphokinetics developments of the embryos. Surprisingly, significantly more patient achieved TOP quality embryos in the DEG group (82.5% vs. 75.8%, P=0.03) and implantation rate and clinical pregnancy rate were comparable as well between the two groups.

Conclusion: DEG at OPU did not change the clinical outcome of IVF. The higher oocyte number and mature oocyte achieved probably compensated the presence of DEG.