A Novel Approach to Infertility Treatment of Advanced-Age Patient with Prominent Intramural Fibroid

Introduction: Ulipristal acetate, a selective progesterone receptor modulator has been currently prescribed for women with symptomatic leiomyomas, prior to and as an alternative to myomectomy. Moreover, already in 2014, Luyckx et al have reported on 21 patients who wished to conceive upon an Ulipristal treatment course completion, 15 of whom (71%) succeeded, for a total of 18 pregnancies.

Aim: To describe a case of infertile advance-age patient with large intramural fibroid, treated with Ulipristal during a course of IVF treatemnt cycles.

Materials & Methods/ Results: We report for the first time on a case of infertile advance-age patient with large intramural fibroid, who conceived following a course of Ulipristal. The patient underwent 2 fresh fertility preserving IVF cycles, with cryopreservation of 9 day-3 embryos, followed by a 12 weeks course of Ulipristal (5mg per day) and a subsequent FET with her own previously cryopreserved embryos.

Conclusions: We therefore believe that Ulipristal is a valuable addition to treatment armamentarium of advance-age infertile patient with prominent intramural fibroid.