BMI Adversely Affect Embryo Quality and Morphokinetics

Introduction:

It is well established that there is a strong correlation between obesity and reproductive pathology including anovulation, infertility and obstetrical complication. We previously demonstrated a significant difference in oocyte’s measurements which correlated with BMI, significantly smaller mature oocytes are retrieved from obese patients.

Aim:

To examine the effect of BMI on embryo’s morphokinetics as reflected by timelaps scores with regard to treatment protocol IVF cycle outcome.

Materials and Methods:

A retrospective cohort study. Records of all fresh cycles that their embryos were cultured in a time-laps incubator were evaluated. Embryos were scored by EmbryoScope™ and correlated with patients BMI and clinical pregnancy rates.

Results:

179 infertile women, total of 2280 oocytes were divided according to their BMI into 3 groups: BMI < 25, BMI 25-29, and BMI ≥30. The duration of treatment was significantly longer for the BMI≥30 (10.2±1.6 days vs. 9.3±2.2 days, respectively). The endometrium was significantly thicker in the BMI≥30 group (10.2±1.6 vs. 9.8±2.4). The Estradiol level on ovulation induction day, the number of oocyte retrieved, the number of oocytes at the M2 phase and the number of the normal fertilization oocyte were significantly higher at the BMI

Conclusion:

Obesity has adverse effect on IVF treatment represented by less TOP quality embryo and a trend of lower pregnancy rate.