One in Ten Take Home Baby Rate following Frozen Oocyte Embryo Transfer (Foet)

Introduction: Oocyte cryopreservation (OoC) has been a medical reality thanks to vitrtification. This enables to preserve oocytes for medical reason and for non-medical (NM) reasons.

Objective: To study the effectiveness of frozen oocyte embryo transfer (FoET) in no-sperm and NM groups.

Materials and Methods: From 2010-2017 we performed 28 FoET cycles (22 no-sperm and 6 NM) Oocytes were vitrified and warmed utilizing the vitrification kit according to the manufacturer instructions (Sage). Intracytoplasmic sperm injection was done 2 hours later using either donor or partner sperm. Embryos were cultured in G1 medium (Vitrolife) and transferred on day 3 in either natural cycle or programmed cycles. The outcomes include oocyte survival, fertilization rate, embryos cleavage, pregnancy and implantation rates.

Results: Patient’s were younger in the no-sperm group (30±5.6y) as compared to the NM group (38.7±1.6y) p<0.05(Ttest). High survival (292/314 (93%)), fertilization (194/292 (66%)) and embryos cleavage (161/194(83%)) rates were obtained to be comparable. Clinical pregnancies per ET were same, 1/5 (20%) in the NM group and 4/20 (20%) in no-sperm group. Implantation rates were 6/36 (16%) in the no-sperm group and 1/11(9%) in the NM group and (NS). One singleton pregnancy in the NM group (age 38 at OoC) ended in miscarriage whereas in the no-sperm group there were two couples of twins, one singleton and the additional pregnancy is ongoing.

Conclusions: We obtain much better results in younger patient group. Therefore patients who consider oocytes presevation due to NM reasons, should be allowed to cryopreserve oocytes at a younger age.