Although regular exercise is an essential requirement for enhancing quality of life in old age, it is not part of the culture of most elderly Nigerians. This study seeks to investigate the relationship between exercise self-efficacy and quality of life, to determine the role of resilience in this association, and to assess whether the association will differ between male and female elderlies in a semi-urban community in Nigeria. A cross-sectional research approach will be employed and data will be collected from older adults (aged 60 years and above) using a convenient sampling technique. Appropriate sample size (A-priori) for two groups (males and females) will be determined using G*Power software given α = .05, f = .04, and power (1-β err prob) = .95. Three standardized psychological instruments will be used to elicit information from the respondents. These are resilience scale (Wagnild & Young, 1993), exercise self-efficacy scale (Kroll, Kehn, Ho, & Groah, 2007), and General Health Questionnaire (GHQ-28) (Goldberg, 1978) will be used to measure quality of life. Structural Equation Modelling (SEM) will be used to test the hypotheses using SPSS AMOS (version 25). Appropriate recommendations will be drawn based on the outcome of the study