Plants are very crucial to the existence of all living things on earth including humans. Aside food production, they are predominant in carbon dioxide and oxygen cycling thereby aiding respiration and in the process sustaining life. Working towards maintaining a good health for these plants is a very important factor for continuous living. Many factors are necessary to consider but we shall be discussing on the aspect of the effect the rhizobiome has on the plant health. As minute as rhizospheric microbes are, their existence is purely based on the plant host in their habitat. They practically depend on the plants for nutrients, and other necessary requirements. There is a strong relationship between the rhizobiome and plant hosts which can be beneficial or pathogenic depending on the microbes involved. This relationship to a large extent, determines the fate of the host plant’s survival. To get the best out of the host plants, research should be directed towards understanding the rhizobiome diversity in the plant’s rhizosphere so that the best modulatory methods and techniques for the rhizobiome for improved plant health can be well understood.